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Monitor Intently (one)phenobarbital will minimize the extent or outcome of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a decrease in fentanyl plasma concentrations, insufficient efficacy or, potentially, development